EZH1 antibody (AA 393-422)

Catalog No. ABIN3030806

The Rabbit Polyclonal anti-EZH1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect EZH1 in samples from Human.

Quick Overview for EZH1 antibody (AA 393-422) (ABIN3030806)

Target: EZH1 (Enhancer of Zeste Homolog 1 (EZH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EZH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-EZH1 Antibody

Binding Specificity: AA 393-422

Cross-Reactivity (Details): Expected species reactivity: Bovine

Purification: Purified

Immunogen: A portion of amino acids 393-422 from the human protein was used as the immunogen for this EZH1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the EZH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the EZH1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for EZH1

Target: EZH1 (Enhancer of Zeste Homolog 1 (EZH1))

Alternative Name: EZH1

Background: EZH1 encodes a protein of 747 amino acids that displays 55 % amino acid identity overall with the Drosophila homolog.1 The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability. EZH1 is expressed as 2 major transcripts in all adult and fetal human tissues evaluated. Analysis of an EZH1 cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggested a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain. The GPR2 gene maps to 17q21.1-q21.3 in the vicinity of the BRCA1 gene.

UniProt: Q92800