GLI2 antibody (C-Term)

Catalog No. ABIN3031039

This Rabbit Polyclonal antibody specifically detects GLI2 in WB, ELISA, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for GLI2 antibody (C-Term) (ABIN3031039)

Target: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-GLI2 Antibody

Binding Specificity: AA 1287-1321, C-Term

Purpose: GLI2 Antibody

Purification: Antigen affinity

Immunogen: This GLI2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1287-1321 amino acids from the C-terminal region of human GLI2.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the GLI2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. GLI-2 exists as five alternatively spliced isoforms of 133 kDa (isoform 1), 132 (2), 88 (3), 86 (4) and 168 kDa (isoform 5).

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GLI2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GLI2

Target: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Alternative Name: GLI2

Background: Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway.

UniProt: P10070

Pathways: Hedgehog Signaling, Dopaminergic Neurogenesis