IGHM antibody (AA 103-131)

Catalog No. ABIN3031293

Product Details anti-IGHM Antibody

Target: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Binding Specificity: AA 103-131

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGHM antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Purification: Purified

Immunogen: A portion of amino acids 103-131 from the human protein was used as the immunogen for this IGHM antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the IGHM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IGHM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for IGHM

Target: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Alternative Name: IGHM (IGHM Products)

Background: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. [UniProt]

UniProt: P01871