IL12B antibody (AA 264-290)
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- Target See all IL12B Antibodies
- IL12B (Interleukin 12 beta (IL12B))
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Binding Specificity
- AA 264-290
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IL12B antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Purification
- Antigen affinity purified
- Immunogen
- A portion of amino acids 264-290 from the human protein was used as the immunogen for this IL-12B antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product IL12B Primary Antibody
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anti-Interleukin 12 beta (IL12B) (AA 30-320) antibody
IL12B Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C2 unconjugated
anti-Interleukin 12 beta (IL12B) (AA 23-327) antibodyIL12B Reactivity: Sheep WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 23-328) antibodyIL12B Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 201-300) antibodyIL12B Reactivity: Human, Mouse WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 264-290), (C-Term) antibodyIL12B Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB28444 unconjugated
anti-Interleukin 12 beta (IL12B) (Internal Region) antibodyVerified IL12B Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (Internal Region) antibodyVerified IL12B Reactivity: Mouse, Rat WB, ELISA Host: Goat Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (AA 229-328) antibodyIL12B Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2H6 unconjugated
anti-Interleukin 12 beta (IL12B) (AA 35-302) antibodyIL12B Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Interleukin 12 beta (IL12B) (C-Term) antibodyIL12B Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Titration of the IL-12B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Western blot: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the IL-12B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- IL12B (Interleukin 12 beta (IL12B))
- Alternative Name
- IL-12B (IL12B Products)
- Background
- IL12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
- UniProt
- P29460
- Pathways
- JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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