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ILK antibody (AA 391-421)

ILK Reactivity: Human, Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031391
$578.58
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  • Target See all ILK Antibodies
    ILK (Integrin-Linked Kinase (ILK))
    Binding Specificity
    • 25
    • 25
    • 23
    • 17
    • 15
    • 10
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 391-421
    Reactivity
    • 172
    • 59
    • 54
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 175
    • 7
    • 5
    Rabbit
    Clonality
    • 180
    • 7
    Polyclonal
    Conjugate
    • 60
    • 17
    • 17
    • 15
    • 11
    • 11
    • 11
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    This ILK antibody is un-conjugated
    Application
    • 108
    • 95
    • 65
    • 40
    • 39
    • 20
    • 20
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Rat, Bovine
    Purification
    Purified
    Immunogen
    A portion of amino acids 391-421 from the human protein was used as the immunogen for this ILK2/ILK1 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the ILK2/ILK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the ILK2/ILK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    ILK (Integrin-Linked Kinase (ILK))
    Alternative Name
    ILK2/ILK1 (ILK Products)
    Synonyms
    CG10504 antibody, CT29478 antibody, DmILK antibody, Dmel\\CG10504 antibody, ILK antibody, ilk antibody, l(3)78Ca antibody, p59 antibody, AA511515 antibody, ESTM24 antibody, zgc:65842 antibody, ILK-1 antibody, ILK-2 antibody, P59 antibody, p59ILK antibody, Integrin linked kinase antibody, integrin linked kinase antibody, integrin linked kinase S homeolog antibody, integrin-linked protein kinase antibody, integrin-linked kinase antibody, Ilk antibody, ILK antibody, ilk.S antibody, CpipJ_CPIJ016644 antibody, Bm1_20815 antibody, Tsp_07213 antibody, Tsp_07224 antibody, Tsp_15354 antibody, ilk antibody
    Background
    Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) is an ankyrin repeat containing 51 kDa receptor-proximate serine-threonine kinase (1), with a reported migration rate of 59K. This 451 amino acid protein interacts with the cytoplasmic domain of the beta-1 integrin subunit and contains sequence motifs found in pleckstrin homology domains capable of interacting with phosphoinositide lipids. ILK is an upstream regulator of Pi(3)K dependant activation of protein kinase B (PKB/AKT) and inhibition of glycogen synthase kinase 3 (GSK-3). ILK2 expression is associated with mediation of cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. ILK2 is overexpressed in some highly invasive tumor cell lines.
    UniProt
    Q13418
    Pathways
    Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration
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