INSRR antibody (AA 16-47)

Catalog No. ABIN3029806

This Rabbit Polyclonal antibody specifically detects INSRR in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for INSRR antibody (AA 16-47) (ABIN3029806)

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSRR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-INSRR Antibody

Binding Specificity: AA 16-47

Purification: Purified

Immunogen: A portion of amino acids 16-47 from the human protein was used as the immunogen for this Insulin receptor-related antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Insulin receptor-related antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Insulin receptor-related antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for INSRR

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Alternative Name: Insulin Receptor-Related

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

UniProt: P14616

Pathways: RTK Signaling