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MAVS antibody (AA 477-505)

MAVS Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031816
$578.58
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  • Target See all MAVS Antibodies
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Binding Specificity
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 477-505
    Reactivity
    • 28
    • 13
    • 3
    • 2
    Human
    Host
    • 30
    • 3
    Rabbit
    Clonality
    • 30
    • 3
    Polyclonal
    Conjugate
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This MAVS antibody is un-conjugated
    Application
    • 22
    • 11
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 477-505 from the human protein was used as the immunogen for this MAVS antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the MAVS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the MAVS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Alternative Name
    MAVS (MAVS Products)
    Synonyms
    CARDIF antibody, IPS-1 antibody, IPS1 antibody, VISA antibody, D430028G21Rik antibody, Visa antibody, cardif antibody, wu:fj20d04 antibody, zgc:158392 antibody, mitochondrial antiviral signaling protein antibody, MAVS antibody, Mavs antibody, mavs antibody
    Background
    Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA and IKKB which activate NFKB, or TBK1 and IKKE (IKBKE, MIM 605048), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB. For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF. For RIGI, the intermediary protein is mitochondria-bound IPS1.
    UniProt
    Q7Z434
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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