MLH1 antibody (AA 452-480)

Catalog No. ABIN3031882

This Rabbit Polyclonal antibody specifically detects MLH1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for MLH1 antibody (AA 452-480) (ABIN3031882)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-MLH1 Antibody

Binding Specificity: AA 452-480

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 452-480 from the human protein was used as the immunogen for this MLH1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the MLH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MLH1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Alternative Name: MLH1

Background: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

UniProt: P40692

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response