MMP2 antibody (AA 303-331)

Catalog No. ABIN3031729

This Rabbit Polyclonal antibody specifically detects MMP2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for MMP2 antibody (AA 303-331) (ABIN3031729)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MMP2 Antibody

Binding Specificity: AA 303-331

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Chicken, Rabbit

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 303-331 from the human protein was used as the immunogen for this MMP2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the MMP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MMP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: P08253

Pathways: Activation of Innate immune Response