MUC4 antibody (N-Term)

Catalog No. ABIN3031870

This Rabbit Polyclonal antibody specifically detects MUC4 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for MUC4 antibody (N-Term) (ABIN3031870)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MUC4 Antibody

Binding Specificity: N-Term

Purification: Antigen affinity purified

Immunogen: This MUC4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human Mucin-4 alpha chain.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the MUC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MUC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Alternative Name: Mucin-4 alpha chain / MUC4

Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity