MAP3K14 antibody (AA 119-148)

Catalog No. ABIN3031848

This anti-MAP3K14 antibody is a Rabbit Polyclonal antibody detecting MAP3K14 in WB, ELISA and IHC. Suitable for Human and Rat.

Quick Overview for MAP3K14 antibody (AA 119-148) (ABIN3031848)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MAP3K14 Antibody

Binding Specificity: AA 119-148

Purification: Purified

Immunogen: A portion of amino acids 119-148 from the human protein was used as the immunogen for this NIK antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the NIK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NIK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: NIK (NF-kappa-beta-Inducing Kinase)

Background: NIK (MAP3K14), a member of the Ser/Thr protein kinase family, binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling