PAK7 antibody (AA 128-157)

Catalog No. ABIN3028909

This Rabbit Polyclonal antibody specifically detects PAK7 in WB, IHC and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for PAK7 antibody (AA 128-157) (ABIN3028909)

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PAK7 Antibody

Binding Specificity: AA 128-157

Purpose: Pak7 Antibody / Pak5

Cross-Reactivity (Details): Expected species reactivity: Rat

Purification: Antigen affinity

Immunogen: A portion of amino acids 128-157 from the mouse protein was used as the immunogen for this Pak7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Pak7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Pak7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAK7

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Alternative Name: Pak7

Background: Pak7, also called Pak5, is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). [UniProt]

UniProt: Q8C015