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PCSK9 antibody (C-Term)

PCSK9 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032340
$578.58
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  • Target See all PCSK9 Antibodies
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Binding Specificity
    • 15
    • 8
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 66
    • 23
    • 23
    Human
    Host
    • 58
    • 9
    • 4
    • 1
    Rabbit
    Clonality
    • 66
    • 6
    Polyclonal
    Conjugate
    • 35
    • 9
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCSK9 antibody is un-conjugated
    Application
    • 52
    • 31
    • 25
    • 13
    • 13
    • 13
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    This PCSK9 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 654-688 amino acids from the C-terminal region of human PCSK9.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PCSK9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PCSK9 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Alternative Name
    PCSK9 (PCSK9 Products)
    Synonyms
    FH3 antibody, HCHOLA3 antibody, LDLCQ1 antibody, NARC-1 antibody, NARC1 antibody, PC9 antibody, AI415265 antibody, AI747682 antibody, Narc1 antibody, proprotein convertase subtilisin/kexin type 9 antibody, proprotein convertase subtilisin/kexin type 9 L homeolog antibody, PCSK9 antibody, pcsk9.L antibody, pcsk9 antibody, Pcsk9 antibody
    Background
    Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
    UniProt
    Q8NBP7
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