PCSK9 antibody (C-Term)

Catalog No. ABIN6145328

The Rabbit Polyclonal anti-PCSK9 antibody (ABIN6145328) specifically detects PCSK9 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for PCSK9 antibody (C-Term) (ABIN6145328)

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK9 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PCSK9 Antibody

Binding Specificity: C-Term

Sequence: CCHAPGLECK VKEHGIPAPQ EQVTVACEEG WTLTGCSALP GTSHVLGAYA VDNTCVVRSR DVSTTGSTSE GAVTAVAICC RSRHLAQASQ ELQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human Proprotein Convertase 9(PCSK9) (NP_777596.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PCSK9

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Alternative Name: PCSK9

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.,PCSK9,FH3,HCHOLA3,LDLCQ1,NARC-1,NARC1,PC9,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Ubiquitin,Endocrine & Metabolism,Amino acid metabolism,Lipid Metabolism,Cholesterol Metabolism,Stem Cells,Neural Stem Cells,Cardiovascular,Lipids,PCSK9

Molecular Weight: 20 kDa/74 kDa

Gene ID: 255738

UniProt: Q8NBP7