Retinoblastoma Protein (Rb) antibody (pSer780)
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- Target See all Retinoblastoma Protein (Rb) (Rb Protein) Antibodies
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Binding Specificity
- pSer780
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Retinoblastoma Protein (Rb) antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Dot Blot (DB)
- Cross-Reactivity (Details)
- Expected species reactivity: Mouse, Rat
- Purification
- Antigen affinity purified
- Immunogen
- This phospho-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS780 of human Rb.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product Rb Protein Primary Antibody
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anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibody
Rb Protein Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibodyRb Protein Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer811) antibodyRb Protein Reactivity: Human ELISA, IHC, IF, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibodyRb Protein Reactivity: Human, Mouse WB, IHC Host: Mouse Monoclonal 172C1094 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibodyRb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer608) antibodyRb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) antibodyRb Protein Reactivity: Human ELISA, IHC Host: Mouse Monoclonal 7E4B8 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibodyRb Protein Reactivity: Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Horse, Bat WB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (N-Term) antibodyRb Protein Reactivity: Human, Mouse, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibodyRb Protein Reactivity: Human, Cow, Dog, Pig, Bat, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Titration of the phospho-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the phospho-Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
- Alternative Name
- Retinoblastoma / Rb (Rb Protein Products)
- Background
- RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
- UniProt
- P06400
- Pathways
- Mitotic G1-G1/S Phases
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