TSC1 antibody (pThr417)

Catalog No. ABIN3029302

This Rabbit Polyclonal antibody specifically detects TSC1 in DB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for TSC1 antibody (pThr417) (ABIN3029302)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Dot Blot (DB), ELISA

Product Details anti-TSC1 Antibody

Binding Specificity: pThr417

Purification: Antigen affinity purified

Immunogen: This phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT417 of rat TSC1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-TSC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

UniProt: Q9Z136

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation