REST antibody (AA 542-570)
REST
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
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- Target See all REST Antibodies
- REST (RE1-Silencing Transcription Factor (REST))
- Binding Specificity
- AA 542-570
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB), ELISA
- Purification
- Antigen affinity purified
- Immunogen
- A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.
- Isotype
- Ig Fraction
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- Application Notes
- Titration of the REST antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the REST antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- REST (RE1-Silencing Transcription Factor (REST))
- Alternative Name
- REST
- Background
- Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
- UniProt
- Q13127
- Pathways
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
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