SOCS7 antibody (AA 458-486)
Quick Overview for SOCS7 antibody (AA 458-486) (ABIN3029049)
Target
See all SOCS7 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 458-486
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Cross-Reactivity (Details)
- Expected species reactivity: Mouse
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Purification
- Antigen affinity purified
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Immunogen
- A portion of amino acids 458-486 from the human protein was used as the immunogen for this SOCS7 antibody.
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Isotype
- Ig Fraction
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anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 6-165) antibody
SOCS7 Reactivity: Human ELISA, WB, IF Host: Rabbit Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 458-486), (C-Term) antibodySOCS7 Reactivity: Human WB Host: Rabbit Polyclonal RB37084 unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (Internal Region) antibodyVerified SOCS7 Reactivity: Human ELISA, WB Host: Goat Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 35-84) antibodySOCS7 Reactivity: Human, Mouse, Rat, Cow, Rabbit, Pig, Bat, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) antibodySOCS7 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Titration of the SOCS7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the SOCS7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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Alternative Name
- SOCS7
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Background
- Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
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UniProt
- O14512
Target
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