SOCS7 antibody (AA 6-165)

Catalog No. ABIN7171009

Product Details anti-SOCS7 Antibody

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Binding Specificity: AA 6-165

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 7 protein (6-165AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7 (SOCS7 Products)

Synonyms: NAP4 antibody, NCKAP4 antibody, SOCS4 antibody, SOCS6 antibody, 2310063P06Rik antibody, C85125 antibody, Nap4 antibody, GB13951 antibody, zgc:175115 antibody, SOCS7 antibody, socs7 antibody, suppressor of cytokine signaling 7 antibody, suppressor of cytokine signaling antibody, SOCS7 antibody, Socs7 antibody, LOC413772 antibody, socs7 antibody

Background:

Background: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Aliases: Ash and phospholipase C gamma-binding protein antibody, NAP 4 antibody, NAP 4 Fragment antibody, NAP-4 antibody, NAP4 antibody, Nck antibody, Nck Ash and phospholipase C binding protein antibody, Nck Ash and phospholipase C gamma binding protein antibody, Nck associated protein 4 antibody, Nck-associated protein 4 antibody, NCKAP4 antibody, SH2 domain containing SOCS box protein antibody, SOCS 7 antibody, SOCS-7 antibody, SOCS4 antibody, SOCS6 antibody, Socs7 antibody, SOCS7_HUMAN antibody, Suppressor of cytokine signaling 7 antibody

UniProt: O14512