SUV39H2 antibody (AA 93-122)

Catalog No. ABIN3029055

This anti-SUV39H2 antibody is a Rabbit Polyclonal antibody detecting SUV39H2 in WB, ELISA and IHC. Suitable for Human and Mouse.

Quick Overview for SUV39H2 antibody (AA 93-122) (ABIN3029055)

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SUV39H2 Antibody

Binding Specificity: AA 93-122

Purification: Purified

Immunogen: A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SUV39H2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SUV39H2

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Alternative Name: SUV39H2 (KMT1B)

Background: The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59 % identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

UniProt: Q9H5I1