SUZ12 antibody (AA 559-588)

Catalog No. ABIN3029056

This Rabbit Polyclonal antibody specifically detects SUZ12 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for SUZ12 antibody (AA 559-588) (ABIN3029056)

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUZ12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SUZ12 Antibody

Binding Specificity: AA 559-588

Purpose: SUZ12 Antibody / Suppressor of zeste 12 protein homolog

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity

Immunogen: A portion of amino acids 559-588 from the human protein was used as the immunogen for this SUZ12 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SUZ12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SUZ12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SUZ12

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Alternative Name: SUZ12

Background: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

UniProt: Q15022