TBK1 antibody (AA 150-181)

Catalog No. ABIN3029094

This anti-TBK1 antibody is a Rabbit Polyclonal antibody detecting TBK1 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for TBK1 antibody (AA 150-181) (ABIN3029094)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TBK1 Antibody

Binding Specificity: AA 150-181

Cross-Reactivity (Details): Expected species reactivity: Mouse, Xenopus

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 150-181 from the human protein was used as the immunogen for this TBK1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TBK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TBK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: TBK1

Background: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

UniProt: Q9UHD2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome