TLK2 antibody (AA 141-171)

Catalog No. ABIN3029189

Product Details anti-TLK2 Antibody

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Binding Specificity: AA 141-171

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogen: A portion of amino acids 141-171 from the human protein was used as the immunogen for this TLK2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TLK2

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Alternative Name: TLK2 (TLK2 Products)

Synonyms: tlk2 antibody, MGC149057 antibody, HsHPK antibody, PKU-ALPHA antibody, wu:fi16h09 antibody, wu:fi30g12 antibody, zgc:136697 antibody, 4933403M19Rik antibody, PKUalpha antibody, Tlk antibody, tousled like kinase 2 antibody, tousled-like kinase 2 antibody, tousled-like kinase 2 (Arabidopsis) antibody, tlk2 antibody, TLK2 antibody, Tlk2 antibody

Background: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

UniProt: Q86UE8