TPSAB1 antibody (AA 61-87)

Catalog No. ABIN3029274

The Rabbit Polyclonal anti-TPSAB1 antibody (ABIN3029274) specifically detects TPSAB1 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for TPSAB1 antibody (AA 61-87) (ABIN3029274)

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPSAB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-TPSAB1 Antibody

Binding Specificity: AA 61-87

Purpose: TPSAB1 Antibody

Purification: Antigen affinity

Immunogen: A portion of amino acids 61-87 from the human protein was used as the immunogen for this TPSAB1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TPSAB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TPSAB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TPSAB1

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Alternative Name: TPSAB1

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

UniProt: Q15661