TRAF1 antibody (AA 55-83)

Catalog No. ABIN3029144

Product Details anti-TRAF1 Antibody

Target: TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))

Binding Specificity: AA 55-83

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 55-83 from the human protein was used as the immunogen for this TRAF1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TRAF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TRAF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TRAF1

Target: TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))

Alternative Name: TRAF1 (TRAF1 Products)

Synonyms: CG3048 antibody, DTRAF antibody, DTRAF1 antibody, Dmel\\CG3048 antibody, TRAF antibody, TRAF1 antibody, Traf1 antibody, dTRAF antibody, dTRAF1 antibody, dTraf1 antibody, dtraf1 antibody, traf1 antibody, traf4 antibody, DKFZp469G032 antibody, EBI6 antibody, MGC:10353 antibody, 4732496E14Rik antibody, TNF receptor associated factor 1 antibody, TNF-receptor-associated factor 4 antibody, TNF receptor-associated factor 1 antibody, TRAF1 antibody, Traf4 antibody, Traf1 antibody, traf1 antibody

Background: The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins, this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.

UniProt: Q13077

Pathways: NF-kappaB Signaling, Apoptosis, Cell-Cell Junction Organization, Asymmetric Protein Localization