TRAF2 antibody (AA 343-372)

Catalog No. ABIN3029149

This Rabbit Polyclonal antibody specifically detects TRAF2 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for TRAF2 antibody (AA 343-372) (ABIN3029149)

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-TRAF2 Antibody

Binding Specificity: AA 343-372

Purpose: TRAF2 Antibody

Purification: Purified

Immunogen: A portion of amino acids 343-372 from the human protein was used as the immunogen for this TRAF2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TRAF2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TRAF2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Alternative Name: TRAF2

Background: TRAF2 regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. [UniProt]

UniProt: Q12933

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins