TRAF3 antibody (AA 490-517)

Catalog No. ABIN3029150

The Rabbit Polyclonal anti-TRAF3 antibody has been validated for WB and ELISA. It is suitable to detect TRAF3 in samples from Human and Mouse.

Quick Overview for TRAF3 antibody (AA 490-517) (ABIN3029150)

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TRAF3 Antibody

Binding Specificity: AA 490-517

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 490-517 from the human protein was used as the immunogen for this TRAF3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TRAF3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TRAF3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TRAF3

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Alternative Name: TRAF3

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

UniProt: Q13114

Pathways: NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades