TSC1 antibody (AA 1117-1144)

Catalog No. ABIN3029279

The Rabbit Polyclonal anti-TSC1 antibody has been validated for ELISA and WB. It is suitable to detect TSC1 in samples from Mouse.

Quick Overview for TSC1 antibody (AA 1117-1144) (ABIN3029279)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-TSC1 Antibody

Binding Specificity: AA 1117-1144

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1117-1144 from the mouse protein was used as the immunogen for this TSC1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TSC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

UniProt: Q9EP53

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation