TSG101 antibody (AA 1-30)

Catalog No. ABIN3029402

Product Details anti-TSG101 Antibody

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Binding Specificity: AA 1-30

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSG101 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this TSG101 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TSG101 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TSG101 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSG101

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Alternative Name: TSG101 (TSG101 Products)

Synonyms: CG9712 antibody, DmTSG101 antibody, Dmel\\CG9712 antibody, ESCRT-I antibody, Tsg101 antibody, burs antibody, dTSg101 antibody, dTsg101 antibody, dVps23 antibody, ept antibody, tsg101 antibody, vps23 antibody, TSG101 antibody, MGC76193 antibody, TSG10 antibody, VPS23 antibody, AI255943 antibody, CC2 antibody, Rw antibody, zgc:86926 antibody, tumor susceptibility 101 antibody, Tumor susceptibility gene 101 antibody, Tumor Susceptibility Gene homolog antibody, tumor susceptibility gene 101 antibody, tumor susceptibility 101a antibody, tumor susceptibility 101 L homeolog antibody, TSG101 antibody, tsg-101 antibody, tsg101 antibody, Tsg101 antibody, tsg101a antibody, tsg101.L antibody

Background: TSG101 is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis, the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. [UniProt]

UniProt: Q99816