XRCC1 antibody (AA 407-435)

Catalog No. ABIN3029645

The Rabbit Polyclonal anti-XRCC1 antibody has been validated for WB, IHC, IF, ELISA and FACS. It is suitable to detect XRCC1 in samples from Human.

Quick Overview for XRCC1 antibody (AA 407-435) (ABIN3029645)

Target: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRCC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Product Details anti-XRCC1 Antibody

Binding Specificity: AA 407-435

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 407-435 from the human protein was used as the immunogen for this XRCC1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the XRCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:25,Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the XRCC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for XRCC1

Target: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Alternative Name: XRCC1

Background: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

UniProt: P18887

Pathways: DNA Damage Repair