TAO Kinase 1 (TAOK1) (C-Term) antibody

Catalog No. ABIN498003

Product Details

Target: TAO Kinase 1 (TAOK1)

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with TAO Kinase 1 (TAOK1).

Cross-Reactivity (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: TAOK1 antibody was raised against synthetic peptide from human TAOK1. .Remarks: Rat Identity: 100% Rat Similarity: 100%

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 5 μg/mL (Requirespretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details

Target: TAO Kinase 1 (TAOK1)

Abstract: TAOK1 Products

Synonyms: TAOK1 antibody, LOC733788 antibody, KFC-B antibody, MAP3K16 antibody, MARKK antibody, PSK-2 antibody, PSK2 antibody, TAO1 antibody, hKFC-B antibody, hTAOK1 antibody, 2810468K05Rik antibody, AU020252 antibody, D130018F14Rik antibody, Map3k16 antibody, Markk antibody, Psk2 antibody, mKIAA1361 antibody, taok1-b antibody, microRNA 4523 antibody, TAO kinase 1 antibody, serine/threonine-protein kinase TAO1 antibody, TAO kinase 1 S homeolog antibody, MIR4523 antibody, TAOK1 antibody, taok1 antibody, LOC100399784 antibody, Taok1 antibody, taok1.S antibody

Background: TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis.Synonyms: KFC-B, KIAA1361, Kinase from chicken homolog B, MAP3K16, STE20-like kinase PSK2, Serine/threonine-protein kinase TAO1, Thousand and one amino acid protein 1

Gene ID: 57551

NCBI Accession: NP_065842

UniProt: Q7L7X3