PMP22 antibody

Catalog No. ABIN498164

The Rabbit Polyclonal anti-PMP22 antibody is suitable to detect PMP22 in samples from Human, Rat and Mouse. It has been validated for WB and IHC (p).

Quick Overview for PMP22 antibody (ABIN498164)

Target: PMP22 (Peripheral Myelin Protein 22 (PMP22))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMP22 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PMP22 Antibody

Specificity: This detects endogenous levels of GAS3 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000. immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for PMP22

Target: PMP22 (Peripheral Myelin Protein 22 (PMP22))

Alternative Name: PMP22

Background: PMP 22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.Synonyms: GAS-3, GAS3, Growth arrest-specific protein 3, PMP-22, Peripheral myelin protein 22

Molecular Weight: approx. 22 kDa

Gene ID: 5376

NCBI Accession: NP_000295

UniProt: Q01453