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CrkL antibody

CRKL Reactivity: Human, Mouse, Rat WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498177
  • Target See all CrkL (CRKL) Antibodies
    CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
    Reactivity
    • 97
    • 71
    • 26
    • 5
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 116
    • 8
    • 2
    • 1
    Rabbit
    Clonality
    • 114
    • 12
    Polyclonal
    Conjugate
    • 45
    • 11
    • 10
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This CrkL antibody is un-conjugated
    Application
    • 77
    • 45
    • 26
    • 26
    • 17
    • 15
    • 13
    • 12
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of CrkL protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product CRKL Primary Antibody
  • Application Notes
    Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8° for one month or (in aliquots) at -20 °C for longer.
  • Target
    CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
    Alternative Name
    CRKL (CRKL Products)
    Synonyms
    CRKL antibody, wu:fa55g05 antibody, wu:fj60e01 antibody, zgc:63469 antibody, 1110025F07Rik antibody, AA589403 antibody, AI325100 antibody, Crkol antibody, CRK like proto-oncogene, adaptor protein antibody, v-crk avian sarcoma virus CT10 oncogene homolog-like antibody, CRKL antibody, crkl antibody, Crkl antibody
    Background
    SH2 and SH3 (Src homology) domains were originally identified as critical functional domains within non-receptor proteins with tyrosine kinase activity. A subset of these proteins appears to exist predominately of SH2/SH3 domains in the absence of detectable catalytic domains. One of the first members of the family to be identified, Crk, is a transformation-specific protein that induces elevation of cellular phosphotyrosine levels, but lacks tyrosine kinase activity itself. A second protein, Nck, consists solely of three SH3 domains and one SH2 domain, while GRB2 contains an SH2 domain flanked on both sides by SH3 domains. A member of this protein class, Crk-L, is encoded by a gene located on chromosome 22, band 11, centromeric of the chronic myelogenous leukemia breakpoint region. Crk-L encodes a 303 amino acid protein with one SH2 and two SH3 domains, and a predicted molecular weight of 36 kDa.Synonyms: Crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like
    Molecular Weight
    approx. 39 kDa
    Gene ID
    1399
    NCBI Accession
    NP_005198
    UniProt
    P46109
    Pathways
    Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor
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