Serotonin Receptor 1E antibody

Catalog No. ABIN498367

This Rabbit Polyclonal antibody specifically detects Serotonin Receptor 1E in WB. It exhibits reactivity toward Human.

Quick Overview for Serotonin Receptor 1E antibody (ABIN498367)

Target: Serotonin Receptor 1E (HTR1E)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1E antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Serotonin Receptor 1E Antibody

Specificity: This antibody detects endogenous levels of SR-1E protein. (region surrounding Ala127)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Serotonin Receptor 1E

Target: Serotonin Receptor 1E (HTR1E)

Background: The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. beta-adrenergic bound to adrenaline activates adenylyl cyclase, while alpha2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the alpha2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1-7 (5HT1-7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.Synonyms: 5-HT-1E, 5-HT1E, 5-hydroxytryptamine receptor 1E

Molecular Weight: approx. 42 kDa

Gene ID: 3354

NCBI Accession: NP_000856

UniProt: P28566

Pathways: JAK-STAT Signaling, cAMP Metabolic Process