ARR3 antibody

Catalog No. ABIN498372

The Rabbit Polyclonal anti-ARR3 antibody (ABIN498372) specifically detects ARR3 in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for ARR3 antibody (ABIN498372)

Target: ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ARR3 Antibody

Specificity: This antibody detects endogenous levels of Arrestin-C protein. (region surrounding Glu374)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ARR3

Target: ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))

Alternative Name: Arrestin C / ARR3

Background: Members of Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Arrestin-C, also known as retinal cone Arrestin-3, X-Arrestin or cArr, is a member of the Arrestin family of proteins. It is predominantly found in the retina and pineal gland and localizes to the inner and outer segments of red-, green- and blue-cone photoreceptors and the inner plexiform regions. Two Arrestin-C isoforms exist due to alternative splicing. Isoform 1 is the mature full length protein and isoform 2 is truncated, ending with an arginine for amino acid residue 359. Arrestin-C expression is stimulated by retinoic acid. It may play a role in retina-specific signal transduction and bind to photoactivated-phosphorylated red/green opsins. In addition, Arrestin-C forms homodimers and oligomers with beta-Arrestins and may regulate beta-Arrestin mediated signaling.Synonyms: ARRX, C-ARR, C-Arrestin, CAR, Cone arrestin, Retinal cone arrestin-3, X-arrestin

Molecular Weight: approx. 40 kDa

Gene ID: 407

NCBI Accession: NP_004303

UniProt: P36575

Pathways: Phototransduction, Thromboxane A2 Receptor Signaling