MALT1 antibody

Catalog No. ABIN498450

The Rabbit Polyclonal anti-MALT1 antibody (ABIN498450) specifically detects MALT1 in WB, IF and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for MALT1 antibody (ABIN498450)

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MALT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MALT1 Antibody

Specificity: This antibody detects endogenous levels of MALT1 protein. (region surrounding asn324)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Alternative Name: MALT1

Background: Mucosa Associated Lymphoid Tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B-cell lymphomas. MALT1 encodes two Iglike C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF-kappaB and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells, and plasma cells.Synonyms: MALT lymphoma-associated translocation, MLT, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase

Molecular Weight: approx. 68 kDa

Gene ID: 10892

NCBI Accession: NP_006776

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins