SGCB antibody

Catalog No. ABIN498534

Product Details anti-SGCB Antibody

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGCB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Sarcoglycan-β protein. (region surrounding Val136)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000. Immnohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for SGCB

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Alternative Name: SGCB (Beta-Sarcoglycan) (SGCB Products)

Synonyms: A3b antibody, LGMD2E antibody, SGC antibody, 43kDa antibody, AI747103 antibody, AI844814 antibody, beta-SG antibody, CG5657 antibody, DmSCG-beta antibody, Dmel\\CG5657 antibody, dscgbeta antibody, scg-beta antibody, beta-sarcoglycan antibody, fa03a05 antibody, wu:fa03a05 antibody, zgc:110833 antibody, sarcoglycan beta antibody, sarcoglycan, beta (dystrophin-associated glycoprotein) antibody, Sarcoglycan beta antibody, SarcoGlycaN antibody, uncharacterized LOC5567384 antibody, beta-sarcoglycan antibody, sarcoglycan, beta antibody, sarcoglycan beta L homeolog antibody, SGCB antibody, Sgcb antibody, Scgbeta antibody, sgn-1 antibody, LOC5567384 antibody, CpipJ_CPIJ006944 antibody, sgcb.L antibody, sgcb antibody

Background: The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.Synonyms: 43 kDa dystrophin-associated glycoprotein, 43DAG, A3b, Beta sarcoglycan, Beta-SG

Molecular Weight: approx. 38 kDa

Gene ID: 6443

NCBI Accession: NP_000223

UniProt: Q16585

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location