NPY antibody

Catalog No. ABIN498562

This Rabbit Polyclonal antibody specifically detects NPY in IHC (p). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for NPY antibody (ABIN498562)

Target: NPY (Neuropeptide Y (NPY))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPY antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NPY Antibody

Specificity: This antibody detects endogenous levels of NPY protein. (region surrounding Pro94)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NPY

Target: NPY (Neuropeptide Y (NPY))

Alternative Name: Neuropeptide Y / NPY

Background: A gene located on chromosome 7p15.1 encodes a 36-amino acid protein designated NPY (Neuropeptide Y). NPY consists of a polyproline stretch followed by an amphipathic alphahelix. NPY shares a 50 % amino acid homology with pancreatic polypeptide gene (PP). The NPY hormone family consists of NPY, PP and peptide YY. NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G-protein coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A leucine(7)-to- proline(7) polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.

Molecular Weight: approx. 11 kDa

Gene ID: 4852

NCBI Accession: NP_000896

UniProt: P01303

Pathways: Feeding Behaviour