HOXB2 antibody

Catalog No. ABIN499088

Product Details anti-HOXB2 Antibody

Target: HOXB2 (Homeobox B2 (HOXB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXB2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of HoxB2 protein. (region surrounding Pro67)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for HOXB2

Target: HOXB2 (Homeobox B2 (HOXB2))

Alternative Name: HOXB2 / HOX2H (HOXB2 Products)

Synonyms: hox2 antibody, hox2h antibody, hox-2.8 antibody, Hoxb-2 antibody, Z-151 antibody, hoxb2 antibody, hm:zehn0229 antibody, HOX2 antibody, HOX2H antibody, Hox-2.8 antibody, K8 antibody, AI894218 antibody, Hoxbes2 antibody, homeobox B2 antibody, homeobox B2a antibody, homeobox protein Hox-B2 antibody, HOXB2 antibody, hoxb2 antibody, hoxb2a antibody, LOC733446 antibody, Hoxb2 antibody

Background: Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene HoxB1 is critical to hindbrain development and has phenotypic features frequently observed in autism. Analysis of expression and targeted disruption of HoxB1 demonstrates that it is also essential for patterning progenitor cells along the entire DV axis of rhombomere 4 (r4). HoxB1 maintains this function by acting very early during hindbrain neurogenesis to specify effectors of the Sonic hedgehog and Mash1 signaling pathways. HoxB2 is a homeodomain protein important in neural development that is also expressed during erythropoiesis, hindbrain development and normal human adult lung development. HoxB2 may modulate the amount of gamma-globin mRNA expressed during development and differentiation. In addition, HoxB2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish.Synonyms: Homeobox protein Hox-B2, Hox-2.8, Hox-2H, K8

Molecular Weight: approx. 38 kDa

Gene ID: 3212

NCBI Accession: NP_002136

UniProt: P14652