Caspase 6 antibody (Intermediate Domain)

Catalog No. ABIN499569

This anti-Caspase 6 antibody is a Rabbit Polyclonal antibody detecting Caspase 6 in WB, IF and EIA. Suitable for Human.

Quick Overview for Caspase 6 antibody (Intermediate Domain) (ABIN499569)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-Caspase 6 Antibody

Binding Specificity: Intermediate Domain

Specificity: Caspase-6 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-6.

Purification: Immunoaffinity

Immunogen: Human Casp-6 / Mch2 (Intermediate Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Casp-6 antibody can be used for the detection of Caspase-6 at 1 μg/mL. MCF7cell lysate can be used as positive control. Depending on cell lines or tissues used, eitherfull-length or other cleavage products may be observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: Caspase-6

Background: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2

Gene ID: 839

NCBI Accession: NP_001217

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis