CDNF antibody (N-Term)

Catalog No. ABIN499611

The Rabbit Polyclonal anti-CDNF antibody (ABIN499611) specifically detects CDNF in WB, IHC (p) and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CDNF antibody (N-Term) (ABIN499611)

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDNF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CDNF Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to CDNF.

Purification: Affinity chromatography purified via peptide column

Immunogen: CDNF antibody was raised against a 12 amino acid peptide from near the amino terminus of human CDNF.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CDNF antibody can be used for detection of CDNF at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CDNF

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Alternative Name: CDNF

Background: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF.Synonyms: ARMET-like protein 1, ARMETL1, Cerebral dopamine neurotrophic factor, Conserved dopamine neurotrophic factor

Gene ID: 441549

UniProt: Q49AH0