CDX2 antibody (C-Term)

Catalog No. ABIN499613

The Rabbit Polyclonal anti-CDX2 antibody is suitable to detect CDX2 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for CDX2 antibody (C-Term) (ABIN499613)

Target: CDX2 (Caudal Type Homeobox 2 (CDX2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDX2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CDX2 Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: CDX2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CDX2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CDX2 antibody can be used for detection of CDX2 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for CDX2

Target: CDX2 (Caudal Type Homeobox 2 (CDX2))

Alternative Name: Cdx2

Background: CDX2 is a member of the caudal homeobox family of transcription factors that also includes the proteins CDX1 and CDX4. CDX2 is strongly expressed in the trophectoderm in the blastocyst with expression maintained within the proliferating extra-embryonic ectoderm during development. It is required for the repression of the transcription of the POU5F1/Oct4 and NANOG genes in the outer cells of the blastocyst and is thus essential for the segregation of the inner cell mass and trophectoderm at the blastocyst stage. Aberrant expression of CDX2 is associated with numerous types of carcinomas, including intestinal metaplasia, gastric carcinoma, and acute myeloid leukemia due to deregulated HOX gene expression.Synonyms: CDX-3, CDX3, Caudal-type homeobox protein 2, Homeobox protein CDX-2

Gene ID: 1045

UniProt: Q99626

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance