SNCA antibody (pSer129) (AbBy Fluor® 680)

Catalog No. ABIN4996378

The Rabbit Polyclonal anti-SNCA antibody has been validated for WB, IF (p), IF (cc) and FACS. It is suitable to detect SNCA in samples from Human, Mouse and Rat.

Quick Overview for SNCA antibody (pSer129) (AbBy Fluor® 680) (ABIN4996378)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNCA antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)

Product Details anti-SNCA Antibody (AbBy Fluor® 680)

Binding Specificity: pSer129

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human SNCA around the phosphorylation site of Ser129 [MP(p-S)EE]

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: Alpha synuclein

Background:

Synonyms: SNCAphospho S129, alpha Synuclein phospho S129 ,alpha-Synuclein Ser129, Synuclein alphaSer129, Alpha synuclein, Alpha-Synuclein, Alpha-synuclein, isoform NACP140, alpha SYN, MGC105443, MGC110988, MGC127560, MGC64356, NACP, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid , precursor of, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK 1, PARK 4, PARK1, PARK4, Parkinson disease autosomal dominant, Lewy body 4, Parkinson disease familial 1, PD 1, PD1, Syn, SNCA, Snca synuclein, alpha non A4 component of amyloid precursor, SYUA_HUMAN, Synuclein alpha, Synuclein, alpha non A4 component of amyloid precursor,

Background: The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor),Beta-synuclein (also designated PNP 14 for neuroprotein 14)and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer?s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson?s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.

Gene ID: 6622

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity