CLIP1 antibody (C-Term)

Catalog No. ABIN499641

The Rabbit Polyclonal anti-CLIP1 antibody (ABIN499641) specifically detects CLIP1 in WB, IF and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CLIP1 antibody (C-Term) (ABIN499641)

Target: CLIP1 (CAP-GLY Domain Containing Linker Protein 1 (CLIP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CLIP1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to CLIP170.

Purification: Affinity chromatography purified via peptide column

Immunogen: CLIP170 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human CLIP170.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CLIP170 antibody can be used for detection of CLIP170 at 0.5 - 1 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CLIP1

Target: CLIP1 (CAP-GLY Domain Containing Linker Protein 1 (CLIP1))

Alternative Name: CLIP1 / Restin

Background: CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.Synonyms: CAP-Gly domain-containing linker protein 1, CLIP-170, CYLN1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, RSN, Reed-Sternberg intermediate filament-associated protein

Gene ID: 6249

NCBI Accession: NP_002947

UniProt: P30622

Pathways: Microtubule Dynamics