DAPK2 antibody

Catalog No. ABIN499708

This Rabbit Polyclonal antibody specifically detects DAPK2 in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DAPK2 antibody (ABIN499708)

Target: DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAPK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-DAPK2 Antibody

Specificity: DAPK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DAPK2. The sequence of this antigenic peptide is identical to the corresponding amino acids of mouse origin (1,2). DAPK2 has no cross responses to DAPK1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human DAP kinase 2 Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 42 kDa band can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for DAPK2

Target: DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

Alternative Name: DAPK2 / DRP-1

Background: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types of cells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues (1).Synonyms: DAP kinase 2, DAP-kinase-related protein 1, Death-associated protein kinase 2

Gene ID: 23604

UniProt: Q9UIK4