Aurora Kinase B antibody (pTyr12) (AbBy Fluor® 680)

Catalog No. ABIN4997080

The Rabbit Polyclonal anti-Aurora Kinase B antibody has been validated for IF (cc) and IF (p). It is suitable to detect Aurora Kinase B in samples from Mouse.

Quick Overview for Aurora Kinase B antibody (pTyr12) (AbBy Fluor® 680) (ABIN4997080)

Target: Aurora Kinase B (AURKB)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase B antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Aurora Kinase B Antibody (AbBy Fluor® 680)

Binding Specificity: pTyr12

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Aurora B around the phosphorylation site of Tyr12

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurora B

Background:

Synonyms: Aurora B phospho Y12, Aurora B phospho T12, AIK2, AIM1, ARK2, AurB, AURKB, Aurora 1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora related kinase 2, Aurora-B, Aurora/IPL1 related kinase 2, IPL1, Serine/theronine kinase 12, Serine/threonine protein kinase 12, STK1, STK12, STK5.

Background: Mahogany (MG), originally identified as a protein involved in pigmentation, acts in conjunction with melanocortin receptors to suppress diet-induced obesity. Mahogany contains a single transmembrane domain, and it is expressed in a broad range of tissues, including the hypothalamus and pigment cells. Mutations within the mahogany gene were shown to rescue agouti-lethal-yellow mutant mice from obesity. The extracellular domain of mouse mahogany is the ortholog of the human protein attractin. Attractin (also designated DPPT-L) is a human serum glycoprotein and is a member of the CUB family of cell adhesion and guidance proteins. Attractin is expressed on activated T cells and is released from the cells 48 to 72 hours after activation.

Gene ID: 9212

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades