BACE2 antibody (AA 101-200) (AbBy Fluor® 680)

Catalog No. ABIN4997143

The Rabbit Polyclonal anti-BACE2 antibody has been validated for IF (cc) and IF (p). It is suitable to detect BACE2 in samples from Rat.

Quick Overview for BACE2 antibody (AA 101-200) (AbBy Fluor® 680) (ABIN4997143)

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BACE2 antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BACE2 Antibody (AbBy Fluor® 680)

Binding Specificity: AA 101-200

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BACE2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BACE2

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Alternative Name: BACE2

Background:

Synonyms: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, UNQ418/PRO852

Background: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Gene ID: 25825

UniProt: Q9Y5Z0