DCLK2 antibody (C-Term)

Catalog No. ABIN499718

The Rabbit Polyclonal anti-DCLK2 antibody is suitable to detect DCLK2 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for DCLK2 antibody (C-Term) (ABIN499718)

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-DCLK2 Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: DCLK2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DCLK2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Alternative Name: Doublecortin-Like Kinase 2

Background: DCLK2 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK2 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.Synonyms: CLICK2, DCAMKL2, DCDC3B, DCK2, DCLK2, DKFZp761I032, Serine/threonine-protein kinase DCLK2

Gene ID: 166614

NCBI Accession: NP_001035350

UniProt: Q8N568