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Beclin 1 antibody (AA 160-190)

This Mouse Monoclonal antibody specifically detects Beclin 1 in WB, IHC (p) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN4997328

Quick Overview for Beclin 1 antibody (AA 160-190) (ABIN4997328)

Target

See all Beclin 1 (BECN1) Antibodies
Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity

  • 185
  • 79
  • 65
  • 9
  • 8
  • 8
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Mouse, Rat

Host

  • 143
  • 51
  • 2
  • 1
Mouse

Clonality

  • 140
  • 57
Monoclonal

Conjugate

  • 117
  • 13
  • 10
  • 9
  • 8
  • 8
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Beclin 1 antibody is un-conjugated

Application

  • 158
  • 81
  • 71
  • 40
  • 37
  • 31
  • 26
  • 25
  • 21
  • 17
  • 13
  • 4
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone

7B12
  • Binding Specificity

    • 16
    • 14
    • 13
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 160-190

    Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein G.

    Immunogen

    KLH conjugated synthetic peptide derived from human Beclin 1

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

    Alternative Name

    Beclin 1

    Background

    Synonyms: Beclin-1, BECN1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197

    Background: Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis, it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

    Gene ID

    8678

    UniProt

    Q14457

    Pathways

    Autophagy
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