EFHD2 antibody (N-Term)

Catalog No. ABIN499784

The Rabbit Polyclonal anti-EFHD2 antibody is suitable to detect EFHD2 in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for EFHD2 antibody (N-Term) (ABIN499784)

Target: EFHD2 (EF-Hand Domain Family, Member D2 (EFHD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFHD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-EFHD2 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: EFHD2 antibody was raised against a 16 amino acid peptide near the amino terminus of human EFHD2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for EFHD2

Target: EFHD2 (EF-Hand Domain Family, Member D2 (EFHD2))

Alternative Name: EFHD2

Background: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.Synonyms: EF-hand domain-containing protein D2, SWS1, Swiprosin 1, Swiprosin-1

Gene ID: 79180

NCBI Accession: NP_077305

UniProt: Q96C19